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Interactive Immune System.

"Immune Cells Puzzle" is a small knowledge level game to sort the hierarchy of the cells of the immune system. Fun educational game to study the types and functions of immune cells. Interactive Immune Cells. Biology learning game, suitable for online lessons and interactive classes. Free online game. Online Biology worksheet. Fun homework biology exercise for 10 grade.


This biology class game include the following cells:
  • Hematopoietic stem cells
  • Innate Immune System (rapid response)
  • Myeloid Progenitor Cell
    Mast Cell
    Neutrophil Cell
    Eosinophil Cell
    Basophil Cell
  • Monocyte
    Macrophage
    Dendritic Cell
  • Adaptive Immune System (slow response)
  • Lymphoid Progenitor Cell
  • Natural Killer Cell
  • T-Cell Progenitor
    Memory T-Cell
    Cytotoxic T-Cell
    Helper T-Cell
  • B-Cell Progenitor
    Plasma Cell
    Memory B-Cell
Immune Cells Puzzle Educational Game

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How to play Immune Cells Puzzle

There are the 18 cells of the immune system at the top of the screen. Drag and drop them either in the Innate Immune System or Adaptive Immune System on the immune cells diagram.


Knowledge Achievements:
Know at least 3 types of immune cells and get +1 Knowledge Level.
Difficulty: Hard.

Immune Cells Puzzle Biology Game Screenshot

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Class subject: Immune System.

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use molecules and cells to perform their functions as following.

  • 1. Hematopoietic stem cells - are the stem cells that give rise to other blood cells. In adults, haematopoiesis occurs in the red bone marrow, in the core of most bones.
  • ==Innate Immune System (rapid response)
    2. Myeloid Progenitor Cell - Myeloids are progenitors precursors of red blood cells, platelets, granulocytes.
    2.1. Mast Cell - A mast cell is a resident cell of connective tissue that contains many granules rich in histamine and heparin.
    2.2. Neutrophil Cell - Neutrophils are the most abundant type of granulocytes and make up 40% to 70% of all white blood cells in humans.
    2.3. Eosinophil Cell - Eosinophils or acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates.
    2.4. Basophil Cell - Basophils release the histamine in their granules during an allergic reaction.
  • 2.5. Monocyte - Monocytes are a type of leukocyte, or white blood cell.
    2.5.1. Macrophage - Macrophages are a type of white blood cell that engulfs and digests anything that does not have, on its surface, proteins that are specific to healthy body cells.
    2.5.2. Dendritic Cell - Dendritics are found in tissues, such as the skin. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems.(*between)
  • ==Adaptive Immune System (slow response)
    3.Lymphoid Progenitor Cell - Progenitors of plasma cell characteristics.
    3.1. Natural Killer Cell(*goes to Innate) - Also known as NK cells they play a role of eradicating infected cells.
  • 3.2. T-Cell Progenitor - &The primary role of progenitor cells is to replace dead or damaged cells. In this way, progenitor cells are necessary for repair after injury and as part of ongoing tissue maintenance.
    3.2.1. Memory T-Cell - Memory T cells are antigen-specific T cells that remain long-term after an infection has been eliminated.
    3.2.2. Cytotoxic T-Cell - Like NK cell, T cell is a T lymphocyte white blood cell, that eradicate cells that are infected, altered or damaged in other ways.
    3.2.3. Helper T-Cell - Helper T cells play a central role in normal immune responses by producing factors that activate virtually all the other immune system cells.
  • 3.3. B-Cell Progenitor - &The primary role of progenitor cells is to replace dead or damaged cells. In this way, progenitor cells are necessary for repair after injury and as part of ongoing tissue maintenance.
    3.3.1. Plasma Cell - Plasma Cell are white blood cells that originate in the lymphoid organs as B lymphocytes and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens.
    3.3.2. Memory B-Cell - These cells develop within germinal centers of the secondary lymphoid organs. Memory B cells circulate in the blood stream in a quiescent state, sometimes for decades.
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